The International HapMap Project
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چکیده
The goal of the International HapMap Project is to determine the common patterns of DNA sequence variation in the human genome and to make this information freely available in the public domain. An international consortium is developing a map of these patterns across the genome by determining the genotypes of one million or more sequence variants, their frequencies and the degree of association between them, in DNA samples from populations with ancestry from parts of Africa, Asia and Europe. The HapMap will allow the discovery of sequence variants that affect common disease, will facilitate development of diagnostic tools, and will enhance our ability to choose targets for therapeutic intervention.
منابع مشابه
A comparison of cataloged variation between International HapMap Consortium and 1000 Genomes Project data
BACKGROUND Since publication of the human genome in 2003, geneticists have been interested in risk variant associations to resolve the etiology of traits and complex diseases. The International HapMap Consortium undertook an effort to catalog all common variation across the genome (variants with a minor allele frequency (MAF) of at least 5% in one or more ethnic groups). HapMap along with advan...
متن کاملThe hapmap project : Nature
| Full Text | PDF (1,269K) | Supplementary information http://www.nature.com/nature/journal/v437/n7063/edsumm/e051027-01.html (1 of 2)12/30/2005 6:56:22 AM The hapmap project : Nature
متن کاملChallenges to public engagement in science and technology in Japan: experiences in the HapMap Project
Public engagement in science and technology has grown in importance as developments in science and technology make increasingly significant impacts on people’s lives. Now, efforts to engage publics in social decision-making or consensusbuilding regarding science and technology involve participation, learning or deliberation opportunities, as well as interactive or coproductive efforts among var...
متن کاملThe International HapMap Project Web site.
The HapMap Web site at http://www.hapmap.org is the primary portal to genotype data produced as part of the International Haplotype Map Project. In phase I of the project, >1.1 million SNPs were genotyped in 270 individuals from four worldwide populations. The HapMap Web site provides researchers with a number of tools that allow them to analyze the data as well as download data for local analy...
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